17. James Gandolfini
James Gandolfini is one of the most tragic cases of a supreme talent being shot down in their prime. The ‘Sopranoes’ star died due to heart complications while having dinner with his son on a vacation. These complications were probably due in large part to his obesity, but they could definitely have been propagated by Gandolfini’s prolific drug addiction earlier in his life. After his messy divorce from ex-wife Marcy, details began to leak about his drug problems that apparently dogged him his entire life.